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Kit de sondas de detección de
Ruptura de genes SYT (SS18)

SYT (SS18) gene break apart probe detection kit

SYT (SS18) gene is located in the q11.2 region of chromosome 18 and encodes a transcriptional co-activator. Specific SYT (SS18) gene translocation exists in 90% of synovial sarcomas.

Probe description

SYT (SS18) gene break apart probe uses an orange dye to label the 5’end region of SYT (SS18) gene and a green dye to label the 3’end region of SYT (SS18) gene. SYT (SS18) gene break apart probe can detect all SYT (SS18) gene rearrangements.

Clinical significance  

Specific chromosomal translocation t (X:18) was found in 90% of patients with synovial sarcoma (p11.2: q11.2). This translocation results in the fusion of the SYT (SS18) gene on chromosome 18 with the SSX1 or SSXE gene on the X chromosome. This is used to assist in the diagnosis of synovial sarcoma.

References

  • Surace C, et al. (2004) Lab Invest 84: 1185-92.
  • Torres L, et al. (2008) Cancer Genet Cytogenet 187: 45-9.

 

Product size: 100μL FISH probe ( ⬤ | ⬤ ) + Pretreatment reagent (10 tests) + Antifade staining solution DAPI (10 tests).